BDBM50140799 CHEMBL282151::[4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizin-10-yl]-phenyl-methanone

SMILES O=C(c1c2CCCCn2c2c(ncnc12)N1CCN(CCc2ccccc2)CC1)c1ccccc1

InChI Key InChIKey=ZPWRQSPJFYPJQB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140799   

LigandPNGBDBM50140799([4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro...)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140799([4-(4-Phenethyl-piperazin-1-yl)-6,7,8,9-tetrahydro...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed