BDBM50140801 4-(4-Phenethyl-piperazin-1-yl)-10-pyrimidin-2-yl-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine::CHEMBL282592

SMILES C(Cc1ccccc1)N1CCN(CC1)c1ncnc2c(c3CCCCn3c12)-c1ncccn1

InChI Key InChIKey=XIKLXZWNLSQCAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140801   

LigandPNGBDBM50140801(4-(4-Phenethyl-piperazin-1-yl)-10-pyrimidin-2-yl-6...)
Affinity DataIC50: 675nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140801(4-(4-Phenethyl-piperazin-1-yl)-10-pyrimidin-2-yl-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed