BDBM50140826 4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylamino]-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile::CHEMBL27841

SMILES N#Cc1c2CCCCn2c2c(NCCN3CCc4ccccc4C3)ncnc12

InChI Key InChIKey=QCPOQIPQWGDZNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140826   

LigandPNGBDBM50140826(4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylamino]...)
Affinity DataIC50: 6.35E+3nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
Xenova

Curated by ChEMBL
LigandPNGBDBM50140826(4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylamino]...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed