BDBM50140931 CHEMBL3753782

SMILES COc1cccc2[nH]cc(\C(=C\c3cccnc3)C#N)c12

InChI Key InChIKey=YEKNWHPJYYLTRW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50140931   

TargetDual specificity protein kinase CLK1(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50140931(CHEMBL3753782)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
TargetKinesin-like protein KIF20A(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50140931(CHEMBL3753782)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of microtubule-stimulated N-terminal MKLP-2 (56 to 505 residues) ATPase activity isolated from human hepatocellular carcinoma cells by pyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
TargetKinesin-like protein KIF20A(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50140931(CHEMBL3753782)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminal MKLP2 (56 to 505 residues) ATPase basal activity isolated from human hepatocellular carcinoma cells by pyruvate kinase/lacta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details Article
PubMed
LigandPNGBDBM50140931(CHEMBL3753782)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of GST-tagged human recombinant DYRK1A expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
LigandPNGBDBM50140931(CHEMBL3753782)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 as substrate after 30 mins in presence of [gamma-33 P] ATP by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed