BDBM50143701 8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione::CHEMBL298595

SMILES Clc1ccccc1N1CCCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1

InChI Key InChIKey=YSSOQZSAWAKBHU-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50143701   

Target5-hydroxytryptamine receptor 1A(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]8-OH-DPAT) as radiolig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  1.38nMAssay Description:Binding affinity to the adrenergic receptor alpha-1D of rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Recordati

Curated by ChEMBL
LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  11.5nMAssay Description:Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  234nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  236nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAlpha-1A adrenergic receptor(Rat)
Recordati

Curated by ChEMBL
LigandPNGBDBM50143701(8-{2-[4-(2-Chloro-phenyl)-[1,4]diazepan-1-yl]-ethy...)
Affinity DataKi:  295nMAssay Description:In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]prazosin in epididymal rat vas deferens.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed