BDBM50143852 CHEMBL65525::{2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-2-oxo-ethoxy}-acetic acid

SMILES NC(=N)c1ccc(cc1)N1CCC2(CCN(CC2)C(=O)COCC(O)=O)C1=O

InChI Key InChIKey=TWXBFWRQAKTFER-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50143852   

TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 17nMAssay Description:Tested for inhibition of the binding of fibrinogen to purified human GPIIb-IIIa in a 96-well format (ELISA assay)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human platelet (h-PRP) aggregation induced by 20 uM ADP with PPACKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 108nMAssay Description:Inhibition of platelet aggregation induced by 20 uM adenosine 5-diphosphate (ADP) in citreated human platelet rich plasma (h-PRP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 273nMAssay Description:Inhibition of citreated human (h-PRP) platelet aggregation induced by 5 uM TRAP6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 393nMAssay Description:Inhibition of citreated human platelet (h-PRP) aggregation induced by 4 ug/mL collagenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 691nMAssay Description:Inhibition of human platelet (h-PRP) aggregation induced by 5 uM TRAP6 with PPACKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 812nMAssay Description:Inhibition of human platelet (h-PRP) aggregation induced by 4 ug/mL collagen with PPACKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143852({2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of vitronectin binding to Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed