BDBM50145795 3-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[b,f]azepin-2-yloxy]-propionic acid::CHEMBL84273

SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(OCCC(O)=O)ccc34)cnc2n1

InChI Key InChIKey=UYSWAPIEBMHQDF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50145795   

TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145795(3-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 4nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range: 3.6-4.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145795(3-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 24nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 19-29More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145795(3-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 28nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range: 25-30More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145795(3-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range: 1100-1200More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed