BDBM50145799 5-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[b,f]azepin-2-yloxy]-pentanoic acid::CHEMBL82936

SMILES Nc1nc(N)c2nc(CN3c4ccccc4C=Cc4cc(OCCCCC(O)=O)ccc34)cnc2n1

InChI Key InChIKey=FVANIGOOFXRYPN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50145799   

TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145799(5-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 7.20nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range: 6.5-8.0More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145799(5-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 11nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range: 9.8-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145799(5-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 21nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range: 20-23More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50145799(5-[5-(2,4-Diamino-pteridin-6-ylmethyl)-5H-dibenzo[...)
Affinity DataIC50: 1.30E+3nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determined; Range: 1100-1500More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed