BDBM50147077 1-(3,5-Bis-trifluoromethyl-phenyl)-3-isoquinolin-5-yl-urea::CHEMBL320906

SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc3cnccc23)cc(c1)C(F)(F)F

InChI Key InChIKey=CKLFTQRSYHFUFQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50147077   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147077(1-(3,5-Bis-trifluoromethyl-phenyl)-3-isoquinolin-5...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147077(1-(3,5-Bis-trifluoromethyl-phenyl)-3-isoquinolin-5...)
Affinity DataIC50: 32nMAssay Description:Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed