BDBM50147078 CHEMBL104445::N-Isoquinolin-5-yl-3-(4-trifluoromethyl-phenyl)-propionamide

SMILES FC(F)(F)c1ccc(CCC(=O)Nc2cccc3cnccc23)cc1

InChI Key InChIKey=VPMLEKNJLRSAQI-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50147078   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147078(N-Isoquinolin-5-yl-3-(4-trifluoromethyl-phenyl)-pr...)
Affinity DataIC50: 38nMAssay Description:Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50147078(N-Isoquinolin-5-yl-3-(4-trifluoromethyl-phenyl)-pr...)
Affinity DataKi:  60nMAssay Description:Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed