BDBM50147457 3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione::CHEMBL109944

SMILES COCCCn1cc(C2=C(C(=O)NC2=O)c2ccccc2O)c2cccnc12

InChI Key InChIKey=DZVIVYUYURSYNH-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50147457   

TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50: 45nMAssay Description:Inhibitory concentration against rabbit glycogen synthase kinase-3 beta using protein phosphatase inhibitor-2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataEC50:  390nMAssay Description:Effective concentration of compound against glycogen synthase kinase-3 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50: 430nMAssay Description:Inhibition of Cyclin-dependent kinase 2-cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50: 700nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Ribosomal S6 kinase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50147457(3-(2-Hydroxy-phenyl)-4-[1-(3-hydroxy-propyl)-1H-py...)
Affinity DataIC50: 4.36E+3nMAssay Description:Inhibitory concentration against human protein kinase C-betaII using histone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed