BDBM50148800 CHEMBL3770486

SMILES Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3ccc4ccccc4c3)s2)n1

InChI Key InChIKey=SCGVCPDSOKXNGR-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50148800   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 400nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 400nMAssay Description:Inhibition of human SIRT2 (25-389 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 400nMAssay Description:Inhibition of human SIRT2 (25-389 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 400nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate after 4 hrs by fluorescence-based microplate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2017
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SIRT1 (133-747 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SIRT1 (133-747 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT3 (101-399 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT3 (101-399 aa) expressed in Escherichia coli BL21 using ZMAL (Z-Lys(Acetyl)-AMC) as substrate incubated for 4 hrs by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50148800(CHEMBL3770486)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed