BDBM50148889 CHEMBL121896::[3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl]-(2-methoxy-ethyl)-propyl-amine::[3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-(2-methoxy-ethyl)-propyl-amine

SMILES CCCN(CCOC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC

InChI Key InChIKey=AKFWXFDMKRSYRD-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50148889   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50148889([3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of [125I]o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50148889([3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity to the cloned human corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50148889([3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo...)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50148889([3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo...)
Affinity DataIC50: 76nMAssay Description:Inhibition of [125I]o-CRF binding to CHO cells expressing human CRF1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed