BDBM50149473 6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::6-(2,4-dichlorophenylthio)-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::CHEMBL331456

SMILES Cc1c(Sc2ccc(Cl)cc2Cl)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=KNRRSDWRVYSYQY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50149473   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Dihydrofolate reductase from Pneumocystis carinii (Pneumocystis carinii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (Mycobacterium avium)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (Toxoplasma gondii)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50149473(6-(2,4-Dichloro-phenylsulfanyl)-5-methyl-7H-pyrrol...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed