BDBM50149566 CHEMBL3769933

SMILES CC(C)Oc1ccc(cc1Cl)-c1nnc(s1)-n1nc2CCN(CCC(O)=O)Cc2c1C

InChI Key InChIKey=BGAJNPLDJJBRHK-UHFFFAOYSA-N

Data  7 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50149566   

TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells by aequorin calcium accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P2 receptor expressed in Saccharomyces cerevisiae after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataEC50: <3.98E+4nMAssay Description:Agonist activity at human S1P4 receptor expressed in CHO-K1 cells by aequorin calcium accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4 by VG metabolism assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) coexpressed in Escherichia coli with human NADPH reductase using 3-butyryl-7-methoxycoumarin as substrate afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP3A4 by VR metabolism assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) coexpressed in Escherichia coli with human NADPH reductase using 4-methylaminomethyl-7-methoyxycoumarin as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) coexpressed in Escherichia coli with human NADPH reductase using 7-methoxy-4-trifluoromethylcoumarin-3-acetic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) coexpressed in Escherichia coli with human NADPH reductase using ethoxyresorufin as substrate after 10 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149566(CHEMBL3769933)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed