BDBM50149638 CHEMBL3770418::US10273223, Compound B-88::US9637472, Compound B-88

SMILES CC(C)n1ncc2c(cc(Br)nc12)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=GSIUYEKHWWAOQS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149638   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149638(CHEMBL3770418 | US9637472, Compound B-88 | US10273...)
Affinity DataIC50: 900nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149638(CHEMBL3770418 | US9637472, Compound B-88 | US10273...)
Affinity DataIC50: 2.00E+3nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149638(CHEMBL3770418 | US9637472, Compound B-88 | US10273...)
Affinity DataIC50: 2.00E+3nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent