BDBM50155575 1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-3-(2-pyrrolidin-1-yl-ethyl)-urea::CHEMBL363926

SMILES Cc1ccc(NC(=O)NCCN2CCCC2)cc1Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=NUZXYWIRCCEMEG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155575   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
The First People'S Hospital of Hangzhou

Curated by ChEMBL
LigandPNGBDBM50155575(1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)...)
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of BCR-ABL kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetBreakpoint cluster region protein(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155575(1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed