BDBM50157853 5-Chloro-3-hydroxy-4a,8a-dihydro-1H-quinazoline-2,4-dione::CHEMBL182687::US11253521, No. 11

SMILES On1c(=O)[nH]c2cccc(Cl)c2c1=O

InChI Key InChIKey=WOBAHOOLQNKVID-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50157853   

TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50157853(5-Chloro-3-hydroxy-4a,8a-dihydro-1H-quinazoline-2,...)
Affinity DataIC50:  0.185nMAssay Description:Inhibitory concentration against the xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFlap endonuclease 1(Homo sapiens (Human))
Ludwig Institute For Cancer Research

US Patent
LigandPNGBDBM50157853(5-Chloro-3-hydroxy-4a,8a-dihydro-1H-quinazoline-2,...)
Affinity DataIC50:  20.8nMAssay Description:Fluorogenic biochemical assays used recombinant full-length FEN-1 or catalytic domains of Exo1, XPG or GEN1 and 200 nM of a DNA substrate (formed by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFlap endonuclease 1(Homo sapiens (Human))
Ludwig Institute For Cancer Research

US Patent
LigandPNGBDBM50157853(5-Chloro-3-hydroxy-4a,8a-dihydro-1H-quinazoline-2,...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibitory concentration against the Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed