BDBM50158076 (2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione::CHEMBL181722

SMILES Oc1c2C3CC(C=C3)c2c(O)n1-c1ccc2cccnc2c1

InChI Key

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50158076   

TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158076((2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158076((2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6...)
Affinity DataIC50: 52nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158076((2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6...)
Affinity DataIC50: 234nMAssay Description:Inhibition of L701H/T877A mutant androgen receptor of human prostate cancer MDAMB-PCa2b cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158076((2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6...)
Affinity DataKi:  530nMAssay Description:Inhibition of [3H]DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50158076((2S,6R)-4-Quinolin-7-yl-4-aza-tricyclo[5.2.1.0*2,6...)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed