BDBM50158340 1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)thiophen-2-yl)methoxy)benzyl)azetidine-3-carboxylic acid::CHEMBL426191

SMILES OC(=O)C1CN(Cc2cc(Cl)c(OCc3cc(c(s3)C(F)(F)F)-c3ccccc3)c(Cl)c2)C1

InChI Key InChIKey=ZEWHUZLAFGAHQV-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158340   

TargetSphingosine 1-phosphate receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataEC50:  2.70nMAssay Description:Activity at human S1P1 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataIC50: 7.5nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataIC50: 33nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataIC50: 640nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158340(1-(3,5-dichloro-4-((4-phenyl-5-(trifluoromethyl)th...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed