BDBM50158612 CHEMBL3787075::US9493483, 401

SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1cnn(C)c1

InChI Key InChIKey=QFLGNZXBWIQDLQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158612   

TargetBromodomain-containing protein 4 [42-168](Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM50158612(US9493483, 401 | CHEMBL3787075)
Affinity DataIC50: 14nMpH: 7.0 T: 2°CAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50158612(US9493483, 401 | CHEMBL3787075)
Affinity DataIC50: 14nMAssay Description:Displacement of biotinylated tetra-acetylated histone H4 from His/Flag-tagged BRD4 bromodomain1 (42 to 168 residues) (unknown origin) incubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [42-168](Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM50158612(US9493483, 401 | CHEMBL3787075)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed and purified to homogeneity. BRD4 binding and inhibition was assessed by monitoring the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent