BDBM50158905 CHEMBL3787674::US11247985, Table 3.61

SMILES CC(C)N1CCN(CCNC2CCN(c3cccc(-c4cc5cc([N+](=O)[O-])ccc5[nH]4)c3)CC2)CC1

InChI Key InChIKey=QOGCSASIXKSUDD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50158905   

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158905BDBM50158905(CHEMBL3787674 | US11247985, Table 3.61 | US1255948...)
Affinity DataIC50: 36nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158905BDBM50158905(CHEMBL3787674 | US11247985, Table 3.61 | US1255948...)
Affinity DataIC50: 36nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158905BDBM50158905(CHEMBL3787674 | US11247985, Table 3.61 | US1255948...)
Affinity DataIC50: 50nMAssay Description:Inhibition of wild type human AAA ATPase p97 expressed in Escherichia coli measured by ADPGlo assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158905BDBM50158905(CHEMBL3787674 | US11247985, Table 3.61 | US1255948...)
Affinity DataIC50: 50nMAssay Description:HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent