BDBM50158906 CHEMBL3785307::US11247985, Table 3.123

SMILES Cc1ccc2[nH]c(-c3cccc(N4CCC(NCCN5CCN(C(C)C)CC5)CC4)c3)cc2c1

InChI Key InChIKey=MZPWQXQUINTXOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50158906   

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158906BDBM50158906(CHEMBL3785307 | US11247985, Table 3.123 | US125594...)
Affinity DataIC50: 200nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158906BDBM50158906(CHEMBL3785307 | US11247985, Table 3.123 | US125594...)
Affinity DataIC50: 200nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetSmall VCP/p97-interacting protein(Human)
University Of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158906BDBM50158906(CHEMBL3785307 | US11247985, Table 3.123 | US125594...)
Affinity DataIC50: 240nMAssay Description:HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2026
Entry Details US Patent

TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158906BDBM50158906(CHEMBL3785307 | US11247985, Table 3.123 | US125594...)
Affinity DataIC50: 240nMAssay Description:Inhibition of p97 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTransitional endoplasmic reticulum ATPase(Human)
University of Pittsburgh

US Patent
LigandChemical structure of BindingDB Monomer ID 50158906BDBM50158906(CHEMBL3785307 | US11247985, Table 3.123 | US125594...)
Affinity DataIC50: 240nMAssay Description:Inhibition of wild type human AAA ATPase p97 expressed in Escherichia coli measured by ADPGlo assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed