BDBM50160284 CHEMBL3785379

SMILES Fc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1

InChI Key InChIKey=XRIROGBLGLPXQI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50160284   

TargetMonoglyceride lipase(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.105nMAssay Description:Inhibition of mouse MAGL using arachidonic acid as substrate preincubated with compound for 30 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.159nMAssay Description:Inhibition of rat MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.198nMAssay Description:Inhibition of human MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of rat MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of rat MAGL expressed in human HeLa cells using 2-arachidonoylglycerol as substrate preincubated with compound for 20 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.357nMAssay Description:Inhibition of mouse MAGL using arachidonic acid as substrate preincubated with compound for 30 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.825nMAssay Description:Inhibition of human MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 0.827nMAssay Description:Inhibition of rat MAGLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant MAGL (1 to 303 residues) expressed in human HeLa cells using 2-arachidonoylglycerol as substrate preincubated with co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMonoglyceride lipase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 10nMAssay Description:Inhibition of MAGL in rat brain membranes preincubated for 20 mins followed by fluorophosphonate-rhodamine addition measured after 30 mins by competi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 195nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 196nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]-CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]-CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2017
Entry Details Article
PubMed