BDBM50160847 1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane-2,6,8,10-tetraone::CHEMBL178509

SMILES O=C1CCC2(N1c1ccc(Oc3ccccc3)cc1)C(=O)NC(=O)NC2=O

InChI Key InChIKey=TVKGACNFKXXAEF-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50160847   

Target72 kDa type IV collagenase(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of TNF-alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed