BDBM50161622 8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL440752

SMILES CC1CNCCc2ccc(Br)cc12

InChI Key InChIKey=KRBZRTWDEJCQIL-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50161622   

Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  12nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  501nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  510nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2A receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed