BDBM50163224 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide::CHEMBL362673

SMILES [O-][N+](=O)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1

InChI Key InChIKey=HFYMEXOYISDCMY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50163224   

TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 74nMAssay Description:Inhibition of human transient receptor potential vanilloid 1 receptor (n=6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163224(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)
Affinity DataIC50: 100nMAssay Description:Inhibition of rat transient receptor potential vanilloid 1 receptor (n=3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed