BDBM50163227 4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide::CHEMBL177428

SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2C(F)(F)F)nc1

InChI Key InChIKey=JYUGYSAVKIDZKF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50163227   

TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human transient receptor potential vanilloid 1 receptor (n=8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50163227(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)
Affinity DataIC50: 102nMAssay Description:Inhibition of rat transient receptor potential vanilloid 1 receptor (n=6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed