BDBM50165873 CHEMBL3800014::US9550781, 19

SMILES Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key InChIKey=PWEHFDUGZVTNNL-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165873   

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165873(US9550781, 19 | CHEMBL3800014)
Affinity DataIC50: 3nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165873(US9550781, 19 | CHEMBL3800014)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165873(US9550781, 19 | CHEMBL3800014)
Affinity DataIC50: 40nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed
TargetNuclear receptor coactivator 2 [740-753]()
Centaurus Biopharma

US Patent
LigandPNGBDBM50165873(US9550781, 19 | CHEMBL3800014)
Affinity DataIC50: 100nMAssay Description:In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50165873(US9550781, 19 | CHEMBL3800014)
Affinity DataEC50:  713nMAssay Description:Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2017
Entry Details Article
PubMed