BDBM50167486 5-(4-Methyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-pyrimidine-2,4,6-trione::5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin-4-yl)methoxy)phenyl)pyrimidine-2,4,6(1H,3H,5H)-trione::CHEMBL193084

SMILES CN1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=HNINPFHHNYDBSH-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50167486   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataIC50: 91nMAssay Description:In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataIC50: 91nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataIC50: 91nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataKi: >2.13E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataKi: >3.33E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataKi: >4.95E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167486(5-(4-methylpiperazin-1-yl)-5-(4-((2-methylquinolin...)
Affinity DataKi: >5.02E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed