BDBM50167488 5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-pyrimidine-2,4,6-trione::CHEMBL371199

SMILES CCCCCCN1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1

InChI Key InChIKey=CKPNTYRTTDOFLD-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50167488   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167488(5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin...)
Affinity DataIC50: 81nMAssay Description:In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167488(5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin...)
Affinity DataKi: >2.13E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167488(5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin...)
Affinity DataKi: >3.33E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167488(5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin...)
Affinity DataKi: >4.95E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167488(5-(4-Hexyl-piperazin-1-yl)-5-[4-(2-methyl-quinolin...)
Affinity DataKi: >5.02E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed