BDBM50168047 3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::CHEMBL366159

SMILES COC(=O)C1C2CCC(CC1c1ccc(F)c(F)c1)N2

InChI Key

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50168047   

TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 5.61nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatal dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataKi:  55.3nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 226nMAssay Description:Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed