BDBM50168387 2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxadiazol-2-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide::2,4-difluoro-5-(5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)-N-methoxybenzamide::CHEMBL365318

SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F

InChI Key InChIKey=DSBPVMDUESDKNK-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50168387   

TargetFibroblast growth factor receptor 1/2/3/4(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 18nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 18nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 86nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition against human HER2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptor (HER-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50168387(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed