BDBM50168695 2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-benzonitrile::CHEMBL175443

SMILES COc1cccc(c1F)-n1c(=O)n(C[C@H](N)c2ccccc2)c(=O)n(Cc2ccccc2C#N)c1=O

InChI Key InChIKey=BZOJHIQSCLXVAL-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50168695   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168695(2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-me...)
Affinity DataKi:  13nMAssay Description:In vitro ability to inhibit des-Gly[125I-Tyr, DLeu, NMeLeu,Pro-NEt]-GnRH radioligand binding to the cloned human GnRH receptor stably expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168695(2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-me...)
Affinity DataKi:  86nMAssay Description:Inhibition constant against monkey GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168695(2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-me...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human GnRH receptor stimulated inositol phosphate accumulation in RBL cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168695(2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-me...)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition constant against rat GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed