BDBM50169438 CHEMBL3804898::US9481677, 63

SMILES Nc1noc2ccc(cc12)-c1cc(Cl)ccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncccn1

InChI Key InChIKey=PMKRZNNFJGGOGE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50169438   

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 4.40nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 570nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using warfarin as substrate after 30 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 30 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone/midazolam as substrate after 30 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50169438(US9481677, 63 | CHEMBL3804898)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed