BDBM50169489 CHEMBL365049::[(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-carbamic acid (S)-2,2-dimethyl-1-[3-(4-trifluoromethyl-phenyl)-pyrazol-1-ylmethyl]-propyl ester

SMILES CCCC[C@H](NC(=O)O[C@H](Cn1ccc(n1)-c1ccc(cc1)C(F)(F)F)C(C)(C)C)C(=O)C(=O)NCc1ccno1

InChI Key InChIKey=XVOFWCZHBSJNKQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50169489   

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169489([(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of 10 lM Cbz-Phe-Arg-AMC binding to human cathepsin K in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169489([(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of 10 lM Cbz-Val-Val-Arg-AMC binding to human cathepsin S in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169489([(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of 2 lM Cbz-Phe-Arg-AMC binding to human cathepsin V activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169489([(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-...)
Affinity DataIC50: 8.70E+5nMAssay Description:Inhibition of 10 lM Cbz-Phe-Arg-AMC binding to human cathepsin B activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50169489([(S)-1-(Isoxazol-5-ylmethyl)-aminooxalyl]-pentyl)-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of 5 lM Cbz-Phe-Arg-AMC bindign to human cathepsin L activity in fluorescence assay with 100 mM NaOAcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed