BDBM50170146 CHEMBL187452::{2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinolin-7-yl}-(4-nitro-phenyl)-methanone

SMILES Oc1ccc(\C=C\c2ccc3ccc(C(=O)c4ccc(cc4)[N+]([O-])=O)c(O)c3n2)cc1O

InChI Key InChIKey=MWJORRZJVOFYKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50170146   

TargetReplicase polyprotein 1ab(2019-nCoV)
New York University

US Patent
LigandPNGBDBM50170146({2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-...)
Affinity DataIC50: 5.20E+3nMAssay Description:Commercially available 2-Hydroxyisoquinoline-1,3(2H,4H)-dione (CAS No: 6890-08-0), a well-known scaffold backbone used to develop human immunodeficie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Unité

Curated by ChEMBL
LigandPNGBDBM50170146({2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory concentration against HIV-1 recombinant integrase activity in standard 3'-processing assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Unité

Curated by ChEMBL
LigandPNGBDBM50170146({2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibitory concentration against HIV-1 recombinant integrase activity in strand transfer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed