BDBM50170181 CHEMBL181393::cis-4-Bromo-N-[4-(4-dimethylamino-quinazolin-2-ylamino)-cyclohexylmethyl]-2-trifluoromethoxy-benzamide

SMILES CN(C)c1nc(NC2CCC(CNC(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12

InChI Key InChIKey=INNDGUNGHHCVFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50170181   

TargetMelanin-concentrating hormone receptor 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170181(cis-4-Bromo-N-[4-(4-dimethylamino-quinazolin-2-yla...)
Affinity DataIC50: 79nMAssay Description:Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170181(cis-4-Bromo-N-[4-(4-dimethylamino-quinazolin-2-yla...)
Affinity DataIC50: 570nMAssay Description:Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170181(cis-4-Bromo-N-[4-(4-dimethylamino-quinazolin-2-yla...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed