BDBM50170224 CHEMBL3804972

SMILES CC(C)C(=O)Nc1ccc(cn1)-c1ccc(NCC(=O)Nc2ccc(CN3CCNCC3)c(c2)C(F)(F)F)cc1

InChI Key InChIKey=LLDMEDJNOJVTEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50170224   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170224(CHEMBL3804972)
Affinity DataIC50: 130nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170224(CHEMBL3804972)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of N-terminal GST-tagged MNK1 kinase domain (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170224(CHEMBL3804972)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) T315I mutant expressed in baculovirus expression system us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170224(CHEMBL3804972)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCR fused full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed