BDBM50171253 CHEMBL193544::N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-5-(1-methylpiperidin-4-yloxy)quinazolin-4-amine::[3-Chloro-4-(pyridin-2-ylmethoxy)-phenyl]-[5-(1-methyl-piperidin-4-yloxy)-quinazolin-4-yl]-amine

SMILES CN1CCC(CC1)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12

InChI Key InChIKey=MKNGJNHUZSCTJU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50171253   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50171253(CHEMBL193544 | N-(3-chloro-4-(pyridin-2-ylmethoxy)...)
Affinity DataIC50:  61nMAssay Description:Inhibitory concentration against erbB2 autophosphorylation in MCF-7 breast carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171253(CHEMBL193544 | N-(3-chloro-4-(pyridin-2-ylmethoxy)...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50171253(CHEMBL193544 | N-(3-chloro-4-(pyridin-2-ylmethoxy)...)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration against EGFR kinase phosphorylation using synthetic peptide as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed