BDBM50172075 CHEMBL3808844::US11053225, Positive control (LDC1267)

SMILES CCOc1cn(nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)-c1ccc(F)cc1C

InChI Key InChIKey=ISPBCAXOSOLFME-UHFFFAOYSA-N

Data  10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50172075   

TargetTyrosine-protein kinase receptor TYRO3(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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Date in BDB:
2/13/2022
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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Date in BDB:
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.80nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 4.90nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:Displacement of kinase tracer 236 from GST-tagged Mer (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assayMore data for this Ligand-Target Pair

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Date in BDB:
10/13/2025
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TargetTyrosine-protein kinase receptor TYRO3(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:Displacement of kinase tracer 236 from GST-tagged Tyro3 (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET ass...More data for this Ligand-Target Pair

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10/13/2025
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TargetHepatocyte growth factor receptor(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  13nMAssay Description:Binding affinity to c-Met in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Inhibition of AXL in human Hs578t cells by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair

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Date in BDB:
9/4/2017
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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

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Affinity DataKd:  19nMAssay Description:Binding affinity to UFO in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetTyrosine-protein kinase receptor UFO(Human)
Korea Research Institute of Chemical Technology

US Patent

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Displacement of kinase tracer 236 from GST-tagged Axl (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assayMore data for this Ligand-Target Pair

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TargetHepatocyte growth factor receptor(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 35nMAssay Description:Displacement of kinase tracer 236 from GST-tagged Met (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assayMore data for this Ligand-Target Pair

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TargetAurora kinase B(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 36nMAssay Description:Displacement of kinase tracer 236 from GST-tagged Aurora B (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET ...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Lck(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 51nMAssay Description:Displacement of kinase tracer 236 from GST-tagged LCK (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assayMore data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Mer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 68nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair

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TargetTyrosine-protein kinase Fer(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  107nMAssay Description:Binding affinity to FER in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  124nMAssay Description:Binding affinity to MAP2K5 in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetTyrosine-protein kinase ABL1(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  154nMAssay Description:Binding affinity to ABL1 in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataKd:  217nMAssay Description:Binding affinity to SRC in human Hs-578T cellsMore data for this Ligand-Target Pair

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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 338nMAssay Description:Displacement of kinase tracer 236 from GST-tagged SRC (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assayMore data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 8(Human)
Medical University Innsbruck

Curated by ChEMBL

LigandBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)Copy SMILESCopy InChI

Affinity DataIC50: 3.18E+3nMAssay Description:Displacement of kinase tracer 236 from GST-tagged CDK8 (unknown origin) assessed as inhibition constant incubated for 1 hr by HTRF based TR-FRET assa...More data for this Ligand-Target Pair

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