BDBM50175503 CHEMBL197696::Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-phenoxy)-ethyl]-2,3-dihydro-1H-benzo[c]azepin-7-yl ester

SMILES CN(C)C(=O)Oc1ccc2[C@@H](CCOc3ccc(cc3)[N+]([O-])=O)N(C)CC=Cc2c1

InChI Key InChIKey=XUOUWGWIRPBWCW-OAQYLSRUSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50175503   

TargetAcetylcholinesterase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse brain acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175503(CHEMBL197696 | Dimethyl-carbamic acid (R)-2-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat synaptosome SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed