BDBM50175757 (2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl)piperidin-1-yl)propanoic acid::CHEMBL199565

SMILES C[C@H](N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O

InChI Key InChIKey=URBUXCDIWBUQDI-INIZCTEOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175757   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175757((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175757((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50:  28nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50175757((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed