BDBM50176545 3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholino)-1-(5-(methylsulfonyl)pyridin-2-yl)-1H-pyrazole-4-carbonitrile::3-(difluoromethyl)-5-((cis)-2,6-dimethylmorpholino)-1-(5-(methylsulfonyl)pyridin-2-yl)-1H-pyrazole-4-carbonitrile::CHEMBL200812

SMILES C[C@H]1CN(C[C@@H](C)O1)c1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F

InChI Key InChIKey=GRLVSXKWMZHINP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50176545   

TargetProstaglandin G/H synthase 2(Human)
Veterinary Medicine Research and Development Pfizer

Curated by ChEMBL
LigandPNGBDBM50176545(3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholi...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against COX2 in feline whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176545(3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholi...)
Affinity DataIC50: 140nMAssay Description:Inhibition of COX2 by canine whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176545(3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholi...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against COX2 in canine whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Dog)
Veterinary Medicine Research and Development Pfizer

Curated by ChEMBL
LigandPNGBDBM50176545(3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholi...)
Affinity DataIC50: 4.38E+4nMAssay Description:Inhibitory activity against COX1 in canine whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Dog)
Veterinary Medicine Research and Development Pfizer

Curated by ChEMBL
LigandPNGBDBM50176545(3-(difluoromethyl)-5-((2R,6S)-2,6-dimethylmorpholi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of COX1 by canine whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed