BDBM50178208 CHEMBL3814706::US10206931, Example 133

SMILES C[C@H]1CC(=O)Nc2ccccc2N1

InChI Key InChIKey=BBPWQLMHOSRDMA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50178208   

TargetBromodomain-containing protein 4 [42-168](Human)
Genentech

US Patent
LigandPNGBDBM50178208(CHEMBL3814706 | US10206931, Example 133)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50178208(CHEMBL3814706 | US10206931, Example 133)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50178208(CHEMBL3814706 | US10206931, Example 133)
Affinity DataIC50: 2.00E+6nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178208(CHEMBL3814706 | US10206931, Example 133)
Affinity DataIC50: 3.70E+6nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed