BDBM50178311 CHEMBL3814010

SMILES CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3ccn(C)c23)c1

InChI Key InChIKey=NYCXATWLUSZHMH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50178311   

TargetSerine/threonine-protein kinase TNNI3K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178311(CHEMBL3814010)
Affinity DataIC50: 16nMAssay Description:Displacement of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TNNI3K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178311(CHEMBL3814010)
Affinity DataIC50: 50nMAssay Description:Inhibition of human myc-tagged TNNI3K autophosphorylation overexpressed in HEKMSR2 cells incubated for 30 mins by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50178311(CHEMBL3814010)
Affinity DataIC50: 130nMAssay Description:Inhibition of full-length His6-tagged BRAF V600E mutant (2 to 766 residues) (unknown origin) expressed in baculovirus system by B-Raf accelerated MEK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed