BDBM50179774 4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2-oxopyrrolidin-1-yl)-4-phenylcyclohexyl)-1-phenylpiperazin-2-one::CHEMBL203961

SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C1CCN(C1=O)[C@]1(CC[C@@H](CC1)N1CCN(C(=O)C1)c1ccccc1)c1ccccc1

InChI Key InChIKey=AILRYHWCZLVQIS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50179774   

TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179774(4-((1r,4r)-4-(3-(3,5-bis(trifluoromethyl)phenyl)-2...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed