BDBM50181498 (4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)((1R,2R,4R)-2-(4-chlorophenyl)-4-(dimethylamino)cyclopentyl)methanone::CHEMBL380691

SMILES CN(C)[C@H]1C[C@H]([C@@H](C1)c1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1

InChI Key InChIKey=VWUNGIMUSCQDHS-UHFFFAOYSA-N

Data  10 KI  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50181498   

TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  1.02nMAssay Description:Agonist activity at the mutant MC4R F184A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at the mutant MC4R Y268F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  9.5nMAssay Description:Agonist activity at the human wild type MC4R expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at the mutant MC4R Y287F expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at the mutant MC4R Y268A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  53nMAssay Description:Agonist activity at the mutant MC4R I125A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at the mutant MC4R F184L expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  114nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I291A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  275nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  305nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human wild type MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  418nMAssay Description:Agonist activity at the mutant MC4R Y287A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  890nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287F expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at the mutant MC4R I291A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  1.02E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y268A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R F184L expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I125A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataEC50:  1.52E+3nMAssay Description:Agonist activity at the mutant MC4R I129A expressed in HEK293 cells by cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  2.12E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R Y287A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181498((4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpip...)
Affinity DataKi:  3.10E+3nMAssay Description:Displacement of [125I]NDP-alpha-MSH from mutant MC4R I129A expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed