BDBM50182839 CHEMBL205799::N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)thiazol-2-yl)-4-(dimethylamino)benzamide

SMILES CN(C)c1ccc(cc1)C(=O)Nc1ncc(SCc2cccc(c2)C(=O)N2CCN(CC2)C(C)=O)s1

InChI Key InChIKey=YLDHRDIOVUTLTI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50182839   

TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human Itk using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Bmx (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Lck (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of Cdk2 (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of Btk (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK-1 (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Tec (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKA (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Syk (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Txk (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKC (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182839(N-(5-(3-(1-acetylpiperazine-4-carbonyl)benzylthio)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ZAP-70 (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed