BDBM50183782 (2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(piperidin-1-yl)-2-((3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl)butanamide::CHEMBL438964

SMILES COc1ccc(cc1)[C@H]([C@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(=O)N1CCCCC1

InChI Key InChIKey=MHYRZRJQEBSULL-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183782   

TargetCollagenase 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  19nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  83nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  187nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataKi:  321nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183782((2R,3S)-N-hydroxy-3-(4-methoxyphenyl)-4-oxo-4-(pip...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed